NBC's hit mockumentary series, "St. Denis Medical," is preparing for an exciting third season, with the notable addition of veteran comedian and actor Damon Wayans. This special guest appearance promises a nostalgic reunion for fans, as Wayans will share the screen once more with his former "In Living Color" co-star, David Alan Grier.

Wayans and Grier Reconnect on Screen

Scheduled to premiere on Monday, November 2, the third season of "St. Denis Medical" will introduce Damon Wayans as Dr. Highland in its inaugural episode. His character is depicted as a charismatic, albeit slightly arrogant, physician who steps in to temporarily cover for David Alan Grier's character, Ron, as Ron recuperates from a surgical procedure. Dr. Highland quickly captivates the hospital staff and patients with his insightful demeanor, leaving only Allison Tolman's character, Alex, unimpressed.

The series, set within the bustling and often chaotic environment of an understaffed Oregon hospital, follows a team of committed doctors and nurses striving to provide exceptional patient care while maintaining their own sanity amidst the daily challenges. Alongside Grier, the ensemble cast features Wendi McLendon-Covey, Allison Tolman, Josh Lawson, Kahyun Kim, Mekki Leeper, and Kaliko Kauahi. The show is executive produced by Eric Ledgin, Justin Spitzer, Simon Heuer, Bridget Kyle, and Vicky Luu under Universal Television.

Wayans and Grier's professional partnership dates back to their breakout roles on the iconic sketch comedy series "In Living Color," a show created by Wayans' brother, Keenen Ivory Wayans. Their collaboration extended to the Fox series "Damon" in 1998, which ran for a single season. More recently, in 2025, Grier joined the Wayans family on stage to celebrate their induction into the NAACP Hall of Fame at the Image Awards, highlighting their enduring camaraderie. Wayans, represented by Verve, has a rich acting history, including roles in "Poppa's House" alongside his son, Damon Wayans Jr., "Lethal Weapon," and the beloved ABC sitcom "My Wife and Kids."

The return of such dynamic duos to the screen reminds us of the enduring power of comedic chemistry and the joy of seeing beloved actors collaborate again. This reunion on "St. Denis Medical" not only promises humor and entertainment but also serves as a testament to the lasting bonds forged in the entertainment industry. For viewers, it's an opportunity to witness two masters of comedy in their element, bringing fresh energy and a touch of nostalgia to a medical setting.